Paclitaxel loaded biodegradable poly (sebacic acidâ€coâ€ricinoleic acid) cylindrical implants for local deliveryâ€in vitro characterization
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Abstract
indigenously developed melt molding technique. Implants were characterized in terms of physicoâ€chemical evaluations, drug content, drug stability and intactness, thermal analysis, drug physical state and crystallinity, surface morphology, hydrolytic degradation, drug release and its kinetics. Prepared implants were yellow and cylindrical in shape with smooth surfaces.Drug in the implants was found to be stable, intact and uniformly dispersed as amorphous state within the polymer matrix.
In vitro release, kinetic studies showed zero order and Korsmeyerâ€Peppas model release being exhibited. Drug release from the polymeric implants was occurred could be as results of diffusion.
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References
Garciaâ€Garcia E, Andrieux K, Gil S, Couvreur P. Colloidal carriers and
bloodâ€brain barrier (BBB) translocation: A way to deliver drugs to the
brain? Int J Pharm 2005;298:274â€92.
Lo EH, Singhal AB, Torchilin VP, Abbott NJ. Drug delivery to damaged
brain. Brain Res Brain Res Rev 2001;38:140â€8.
Bodor N, Buchwald P. Recent advances in the brain targeting of
neuropharmaceuticals by chemical delivery systems. Adv Drug Deliv
Rev 1999;36:229â€54.
Gelderblom H, Verweij J, Nooter K, Sparreboom A. Cremophor EL: The
drawbacks and advantages of vehicle selection for drug formulation.
Eur J Cancer 2001;37:1590â€8.
Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J
Pharm 2002;235:179â€92.
Feng SS, Chien S. Chemotherapeutic engineering: Application and
further development of chemical principals for chemotherapy of cancer
and other diseases. Chem Eng Sci 2003;58:4087â€114.
Katti DS, Lakshmi S, Langer R, Laurencin CT. Toxicity, biodegradation
and elimination of polyanhydrides. Adv Drug Deliv Rev 2002;54:933â€61.
Kumar N, Langer RS, Domb AJ. Polyanhydrides: An overview. Adv Drug
Deliv Rev 2002;54:889â€910.
Rothenâ€Weinhold A, Besseghir K, Vuaridel E, Sublet E, Oudry N, Kubel F,
et al. Injectionâ€molding versus extrusion as manufacturing technique
or the preparation of biodegradable implants. Eur J Pharm Biopharm
;48:113â€21.
Krasko MY, Shikanov A, Ezra A, Domb AJ. Poly (ester anhydride)s
prepared by the insertion of ricinoleic acid into poly (sebacic acid).
J Polym Sci A Polym Chem 2003;41:1059â€69.
Horikoshi S, Sato H, Wang MY. Inâ€vitro and inâ€vivo evaluation of taxol
release from poly (lacticâ€coâ€glycolic acid) microspheres containing
isopropyl myristate and degradation of the microspheres. J Control
Release 1997;49:157â€66.
Hiremath JG, Rudani1 CG, Suthar1 RV, Domb AJ. Tamoxifen citrate loaded
biodegradable poly (sebacic acidâ€coricinoleic acid) microparticles,
in vitro characterization. J Drug Deliv Sci Technol 2011;21:417â€22.
Park ES, Maniar M, Shah JC. Influence of model compound on their
release from biodegradable polyanhydrides devices. J Control Release
;48:67â€78.
Domb AJ, Nudelman R. In vivo and in vitro elimination of aliphatic
polyanhydrides. Biomaterials 1995;16:319â€23.
Shikanov A, Ezra A, Domb AJ. Poly (sebacic acidâ€coâ€ricinoleic acid)
biodegradable carrier for paclitaxel – Effect of additives. J Control
Release 2005;105:52â€67.
Siepmann J, Siepmann F. Mathematical modeling of drug delivery. Int
J Pharm 2008;364:328â€43.
Hiremath JG, Kusum DV, Kshama D, Domb AJ. Biodegradable
poly (sebacic acidâ€coâ€ricinoleicâ€ester anhydride) tamoxifen citrate
implants: Preparation and in vitro characterization. J Appl Polymer Sci
;107:2745â€54.
Costa P, Sousa Lobo JM. Modeling and comparison of dissolution
profiles. Eur J Pharm Sci 2001;13:123â€33.