Preparation and characterization of mucoadhesive microcapsules of salbutamol sulfate

Pradnya Patil, N G Raghavendra Rao, Doddayya Hiremath

Abstract


Salbutamol sulfate microcapsules with a coat consisting of sodium alginate and mucoadhesive polymer such as sodium carboxy methyl cellulose (NaCMC), methyl cellulose (MC), carbopol-934, and hydroxy propyl methyl cellulose (HPMC) were
prepared by ionotropic gelation technique and were evaluated for morphological characters, drug content, loading efficiency, drug–polymer interactions, swelling ratio, mucoadhesive properties, and in vitro release. The resulting  microcapsules were discrete, spherical, and free-flowing, and microencapsulation efficiency was 51.28–96.70%.The microcapsules prepared with alginate alone (A4) have exhibited good mucoadhesive property in the in vitro washoff test.The swelling ratio of microcapsules was enhanced with increased alginate concentration. Salbutamol sulfate release from these mucoadhesive microcapsules was
slow and extended over a period of 8 h and depends upon the concentration of the alginate. The drug release from alginate- HPMC/carbopol microcapsules followed diffusion-controlled first-order kinetics. The release rate of alginate-HPMC
microcapsules (A4H) was higher than other formulations and comparable with commercially available controlled-release capsules. Microcapsules with alginate alone (A4) followed diffusion mechanism. In conclusion, alginate-HPMC/carbopol
mucoadhesive microcapsules could be promising vehicle for oral controlled release of salbutamol sulfate.


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References


Lauwo JA, Agarwal DK, Emenike IV., Some pharmaceutical studies on

Sustained release Co precipitates of Ampicillin trihydrate with acrylic

resin. Drug Dev Ind Pharm 1990: 16:1375-89.

Bodmeier R, Chen H, Tyle P, Jarosz P., Pseudoephedrine HCl

microspheres formulated into an oral suspension dosage form. J Control

Rel 1991; 15:65,77.

Microcapsule Processing and Technology. In: Kondo A. editor. New York,

Marcel Decker, Inc., 1979, p. 18.

Microcapsules and Microencapsulation Techniques. In: Gutcho MH,

editor., New Jersey: NOYES data Corporation: 1976, p. 236.

Ikeda K, Murata K, Kobayashi N, Noda K., Enhancement of bioavailability of dopamine via nasal route in beagal dogs., Chem. Pharm. Bull. (Tokyo) 1992: 40: 2155-8.

Nagai T, Nishimoto Y, Nambu N, Suzuki Y, Sekine K J., Powder dosage

form of insulin for nasal administration. Control. Release, 1984: 1, 15.

Illum L, Ferraj NF, Critcheley H, Davis SS., Bioadhesive Microspheres as a Potential Nasal Drug Delivery System," Int. J. Pharm., 1988: 46, 261.

Kim CK, Lee EJ. The controlled release of blue dextran from alginate

microspheres. Int. J. Pharm., 1992: 79, 11.

Hari PR, Chandy T, Sharma CP., Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin., J. Microcapsule, 1996: 13, 319-29.

Chowdary KPR, Rao YS., Design in-vitro evaluation of Mucoadhesive

Microcapsules of Glipizide for oral controlled release: a technical note.

AAPS Pharm Sci Tech 2003: 4. E39.

Lehr CM, Bowstra JA, Tukker JJ, Junginer HE. Intestinal transit of

bioadhesive microspheres in an in situ loop in the rat. J Control Release

;13:51-62.

Volland C, Wolff M, Kissel T. The influence of terminal gamma-

sterilization on Captopril containing poly [d,l-lactide-co-glycolide]

microspheres. J Control Release 1994; 31:293-305.

Chowdary KPR, Rao YS. Preparation and evaluation of mucoadhesive

microcapsules of indomethacin. Indian J Pharm Sci 2003: 65: 49-52.




DOI: http://dx.doi.org/10.22377/ajp.v4i2.138

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