Clinical studies and antimicrobial activity of ciprofloxacin hydrochloride medicated dental gels for periodontal infection
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Abstract
formulations are subjected to various physicochemical studies like pH, spreadability, extrudability, viscosity, drug content, in vitro drug release, and rheological and stability studies. During the rheological studies plots of shear rate versus viscosity showed that all the gels were non-Newtonian and exhibited pseudoplastic behavior. in vitro drug release studies were carried
out in the diffusion cell using a pH 7.2 phosphate buffer as a receptor medium. Formulations exhibited an extended release of the drug for over a period of 6 hours and the release depended on the type of polymer and concentrations of propylene glycol used. Stability studies showed no significant variations (P > 0.05) in pH, spreadability, viscosity, extrudability, and drug content. An in vitro release study concluded that hydrocolloid based ciprofloxacin hydrochloride medicated dental gels appear to be probably extend the release of ciprofloxacin hydrochloride. Optimal formulations were selected for in vivo or
clinical studies. The clinical evaluation of ciprofloxacin hydrochloride gels was carried out to determine the efficacy in the treatment of periodontitis. Six groups, each containing five patients, were used in the study. All the patients were evaluated for plaque index (PI) and gingival index (GI), probing depth (PD), and bleeding on probing (BOP). In all these studies, two groups were treated with formulations alone and another two groups were treated with formulations along with scaling and root planning. One group was treated with scaling and root planning only, whereas, the last group was treated as control (No
treatment). All the groups showed a similar baseline PI. However, the PI values decreased remarkably in the groups treated with formulation along with scaling and root planning when compared to the other groups. Similarly, the results of GI, BOP, and PD also showed a significant reduction (P < 0.05) in the groups treated with formulation along with scaling and root planning compared to other groups. The above studies revealed that the adjunctive use of ciprofloxacin hydrochloride gels along with scaling and root planning results in significant benefits, in the treatment of periodontitis.
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References
Yeom RH, Park YJ, Lee SJ, Rhyu JC, Chang CP, Nisengard RJ.
Characterization of bioadhesive periodontal and oral mucosal drug
delivery. J. Periodontal 1998;68:1102.
David C J, Olkovsky, Sebastiam. In: Clinical Periodontology. Fermin A,
Carranza and Michael G, editors. Newman. Bangalore: Prism Books Pvt.
Ltd.; 1996. p. 511.
Klaus H. Color Atlas of Dental Medicine. In: KH Ratietschak, editor.
nd ed. J. Periodontology, and Expanded edition. p. 36-41, 314-8.
Rehaman S, Ashiya A, Khar RK. “Site Specific Delivery System for the
treatment of Periodontitis. Indian J Pharma Sci 2003. p. 106-112.
Realdon N, Ragazzi E, Zotto MD, Dalla Fini G. Possibility of conveying a
cationic drug in carbomer hydrogels. Drug Dev Ind Pharm 1998;24:337-43.
Bureau of Indian Standards. Indich Standards of Toothpaste
specification. New Delhi: Second revision; 1993. p. 1-11.
Tas C, Ozakan Y, Savaser S, Baykara T. in vitro release studies of
chlorophenermine maleate from gels prepared by different cellulose
derivatives. Farmaco 2003;58:605-11.
Bureau of Indian Standards. Indich Standards of Toothpaste
specification. New Delhi: Second revision; 1993. p.1-11.
Hsueh-Ling SW, Susan CM. In vitro release of nicotinic acid alkyl esters
from poloxamer vehicles. Eur J Pharm Bio Pharm 1990;66:213-21.
Cruickshank JP, Duguid BP, Marimion, Swain RH. Medical Microbiology.
Vol. 2. Churchil Livingstone: Edinburg; 1975. p. 190.
Loe H, Silness P. Periodontal disease in pregnancy. I. Prevalence and
severity. Acta Odontol Scand 1963;21:533-51.
Silness P, and Loe H. Periodontal disease in pregnancy. Acta Odontol.
Scand., 22, 1964, 121.
Valdimir W, Spolsky. Epidemiologists of gingival and periodontal disease
Chapter 5 In Fermin A. Caranza and Newman, M.G., (ed.) Clinical
Periodontology, Prism Books Pvt. Ltd., Bangalore, 1996, pp 61-81.
Arellano A, Santoyo S, Martin C, Ygartua P. Influence of propylene glycol
and isopropyl myristate on the in vitro percutaneous penetration of
diclofenac sodium from carbopol gels. Eur J Pharm Sci 1998;7:129-35.
Goundaliya DP, Pundarikakshudu K. Studies on penetration,
characterization and transdermal permeation of nimesulide from
aqueous and emulgel. Ind Drugs 2002;39:465-73.
Lippold BC. How to optimize drug penetration through the skin. Pharm
Act Helv 1992;67:294-300.
el Gendy AM, Jun HW, Kassem AA. in vitro release studies of flurbiprofen
from different topical formulations. Drug Dev Ind Pharm 2002;48:823-31.
Guangwei L, Jun HW. Diffusion studies of methotrexate in carbopol
and poloxamer gels. Int J Pharm 1998;160:1-9.
Hill RW, Ramfjord SP, Morrison EC, Appleberry EA, Caffesse RG, Kerry GJ,
et al. Four types of periodontal treatment compared over two years.
J Periodontal 1981;52:655-62.
Caffesse RG, Sweeney PL, Smith BA. Scaling and root planning with and
without periodontal flap surgery. J Clin Periodontal 1986;13:205-10.