Sustained release tablet of theophylline by hot melt wax coating technology

Amol Padsalgi, Sanjay Bidkar, Vijay Jadhav, Deepak Sheladiya

Abstract


Coating is one of the effective method used for sustaining the release of dosage form. There are various hydrophilic and hydrophilic polymers which are use to sustain the drug release. Waxes are one of the material which can be use to coat
the drug in order to control the release. Coating with waxes can be achieved by dissolving it in suitable solvent or by hot melt wax coating. Hot melt coating technique defined as the application of fine layer of coating material in molten state over the substrate. Hot melt coating technique is widely used to coat granules, pellets and tablets in order to sustained the drug release, mask the bitter taste of drug, improve stability etc. Hot melt wax coatings have various advantages over wax solution coating. Toxicity of the organic solvent residues and the influence of environmental protection are major problems associated with solvent coating. The main goal of this study was to study the effect of different coating technique i.e. pan spray method and pan pour method on release pattern of theophylline and also to study the effect of different pore former
like sodium laurel sulphate (SLS) and hydroxyl propyl methyl cellulose (HPMC) on release pattern. It was found that pan spray technique is the best technique to control the release due to uniform film formation, while pan pour method showed
variation in release of drug from same batch this was due to non uniform coating of tablets and very low coating efficiency. If we compare the effect of pore former it was found that release of drug can be controlled by using suitable concentration of pore former while faster release was seen when SLS was used as a pore former in lower concentration than HPMC.


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References


Porter SC, Bruno CH. Coating of pharmaceutical dosage forms. In:

Liebermann HA, Lachman L, Schwartz JB, editors. Pharmaceutical

Dosage Forms: Tablets, 2nd ed. Vol. 3, New York: Marcel Dekker; 1990.

p. 83-5.

Seitz JA, Mehta SP, Yeager JL. Tablet Coating. In: Lachman L,

Liebermann HA, Kanig J editors. The Theory and Practice of Industrial

Pharmacy, 3 rd ed. Mumbai: Varghese Publishing House; 1987.

p. 346-72.

Crank J, Park GS. Diffusion in Polymers. New York: Academic Press;

p. 1-37.

Lin WJ, Yu CC. Comparison of protein loaded poly (caprolactone)

micro particles prepared by the hot-melt technique. J. Micro Encapsul

;18:585-92.

Lehmann K. Coating of multiparticulates using polymeric solutions:

Formulation and process considerations. In: Multiparticulate oral drug

delivery, 1st ed, I. Ghebre-Sellassie; New York: Marcel Dekker, Inc; 1994.

p. 51-78.

Swarbrick J, Boylan JC. In: Encyclopedia of Pharmaceutical Technology,

nd ed. Vol. 1, New York: Marcel Dekker, Inc.; 1998. p. 338-9.

Paper presentation at the Midwest Regional Meeting, Academy of

Pharmaceutical Sciences, Industrial Pharmaceutical Technology Section;

p. 1-11.

Tang L, Schwartz JB, Porter SC, Schanaare RL, Wigent RJ. Drug release

from film-coated chlorpheniramine maleate nonpareil beads: Effect of

water-soluble polymer, coating level, and soluble core material. Pharm

Dev Tech 2000;5:383-90.

Bodmear R, Paeratakul O. Theophylline tablet coated with aqueous

latex containing dispersed pore former. J Pharm Sci 2007;79:925-8.

Seminoff, Leah A. Cellulosic coating. United States Patent 5126146.

Kibbe AH. Handbook of Pharmaceutical Excipients. 3rd ed. London, UK:

Pharmaceutical Press; 2000. p. 94-5.

Yonezawa Y, Ishida S, Sunanda H. Release from or through a wax

matrix system: I, Basic release properties of the wax matrix system.

Chem Pharm Bull 2001;49:1448-51.




DOI: http://dx.doi.org/10.22377/ajp.v2i1.162

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