Preungual drug delivery systems of Terbinafine Hydrochloride Nail Lacquer
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Abstract
drug, and the formulations were prepared with and without polymer Eudargit RL 100 (Eu) within the concentration range of 1% to 5% (w/v) in the polymeric system. Then, these lacquers were compared for glossiness, film formation, drying rate, smoothness of flow, and nonvolatile content,The in vitro studies were preformed on the artificial membrane and bovine hooves in solvent A (phosphate buffer, pH 7.4; and methanol, AR grade, in the ratio of 4:1). The result obtained indicated that the nail lacquer formulation F2 (1.3% of the drug and 1.3% of Eudargit RL100) showed good release of the drug. Thus nail lacquers can be used as a successful tool for targeted drug delivery for onychomycosis.
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References
Ghannoum MA, Hajjen RA. Large scale North American study of fungal
isolates from nails: The frequency of onychomycosis fungal distribution and
antifungal susceptibility patterns. J Am Acad Dermatol 2002;43:641-8.
Midgley G, Moore MK, Cook JC. Mycology of nail disorders. J Am Acad
Dermatol 1994;31:68-74.
Drake LA, Scher RK, Smith EB, Faich GA, Simto SL, Hong JJ, et al. Effect
of onchomycosis on quality of life. J Am Dermatol 1998;38:702-4.
Nierwerth M, Korting HC. Management of onchomycosis. Drugs
;58:283-96.
Baran R, Dawber R, Ecakart H, Tosti A. Onychomycosis and its treatment:
A text Atlas of Nail disorders techniques in investigation and diagnosis.
London: Martin Dunitz Ltd; 1996. p. 155-67.
Hay RJ. The future of onchomycosis therapy may involve a combination
of approaches. Br J Dermatol 2001;145:3-8.
Murdan S. Drug delivery to the nail following topical application. Int
J Pharma 2002;236:1-26.
Marty JP. Amorolfine nail lacquer a novel formulation. J Eur Acad
Dermatol Venerol 1995;4:S17-21.
Marzo A. Study IPAS-CICLOPRIOX-238-00: Application of Ciclopirox on
finger nails: A preliminary study to evaluate the amount of drug applied
and removed by hands washing Polichem SA, 2000. Data on file.
Bayeri TM. Measurement of ciclopirox: Permeation through fingernail
model by novel spectroscopic techniques. In: Shuster S, editor. Hydroxy-
pyridones as antifungal agents with special emphasis on onchomycosis.
Berlin: Springer-Verlag; 1999. p. 36-8.
Tripathi KD 5th, editors. Essentials of medical pharmacology. 2003. p.
-24.
Balsam, Sagarin. Cosmetics; Science and Technology, 2nd ed, Vol 1, 1992. p. 537-8.
Murdan S. Drug delivery to the nail following topical application. Int
J Pharma 2002;236:1-26.
Baden HP, Gold Smith LA, Fleming B. Comparative study of the
physicochemical properties of human keratinized tissues. Biochimica
Biophysics ET Acta 1973;322:269-78.
Mertin D, Lippold BC. In vitro permeability of the human nail and of a
keratin membrane from bovine hooves: Prediction of the penetration
rate of antimycotic through the nail plate and their efficacy. J Pharma
Pharmacol 1997c;49:866-72.
Mertin D, Lippold BC. In vitro permeability of the human nail and of a
keratin membrane from bovine hooves: Penetration of chloramphenicol
from lipophillic vehicles and a nail lacquer. J Pharma Pharmacol
b;49:241-5.