Solubility enhancement and development of dispersible tablet of meloxicam

Nazma Inamdar, Kiran Bhise, Shakeel Memon

Abstract


The present research work investigates enhancement of dissolution profile of meloxicam using solid dispersion (SD) with various polymers. The work also describes the formulation of dispersible tablet (DT) and effervescent tablet of
meloxicam. PEG 6000, PEG 8000, PEG 20000, Lutrol F-127, and β-cyclodextrin were selected for the preparation of SD. The SDs were prepared by melting and solvent evaporation methods. Dissolution studies were performed for plain
meloxicam, SDs, and tablet formulations. Infrared spectroscopy and differential scanning calorimetry were performed to identify the physicochemical interaction between drug and carriers. Dispersible tablets and effervescent tablets were
compared with tablet containing plane drug for dissolution profile. Dissolution of DT improved significantly in SD product
(<95% in 1 min).


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DOI: http://dx.doi.org/10.22377/ajp.v2i2.190

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