Novel method for spectrophotometric analysis of hydrochlorothiazide tablets using niacinamide as hydrotropic solubilizing agent

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Published: Aug 26, 2014
DOI: https://doi.org/10.22377/ajp.v2i1.178

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R K Maheshwari
Ravi Shankar Shukla

Abstract

In the present investigation, 2 M niacinamide (an inexpensive drug) solution was employed as hydrotropic solubilizing agent to solubilize poorly water-soluble drug hydrochlorothiazide for its spectrophotometric analysis. The proposed
method is new, simple, environmentally friendly, accurate, and reproducible. Accuracy, reproducibility, and precision of the
proposed method were validated statistically.

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How to Cite
Maheshwari, R. K., & Shukla, R. S. (2014). Novel method for spectrophotometric analysis of hydrochlorothiazide tablets using niacinamide as hydrotropic solubilizing agent. Asian Journal of Pharmaceutics (AJP), 2(1). https://doi.org/10.22377/ajp.v2i1.178
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Vol. 2 No. 1 (2008): Jan-Mar
Section
Articles

This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.

References

Maheshwari RK. “Simultaneous spectrophotometric estimation of

norfloxacin and tinidazole in two component tablet formulationsâ€

Asian J Chem 2006;18:1481.

Maheshwari RK.â€Novel application of hydrotropic solubilization in the

spectrophotometric analysis of piroxicam in solid dosage form†Indian

Drugs 2006;43:683.

Maheshwari RK. “Novel application of hydrotropic solubilization in

the spectrophotometric analysis of tinidazole in dosage formâ€, Asian

J Chem 2006;18:640.

Maheshwari RK. “A novel application of hydrotropic solubilization in

the analysis of bulk samples of ketoprofen and salicylic acid†Asian J

Chem 2006;18:393.

Maheshwari RK. “Analysis of frusemide by application of hydrotropic

solubilization phenomenon†The Indian Pharmacist IV 2005;55.

Maheshwari RK. “Spectrophotometric determination of cefixime

in tablets by hydrotropic solubilization phenomenonâ€, The Indian

Pharmacist IV 2005;63.

Maheshwari RK. “Application of hydrotropic solubilization phenomenon

in spectrophotometric estimation of norfloxacin in tabletsâ€, Indian J

Pharm Edu Res 2006;40:237.

Maheshwari RK. “New application of hydrotropic solubilization in the

spectrophotometric estimation of ketoprofen in tablet dosage formâ€,

Pharma Rev 2005;3:123.

Maheshwari RK. “A novel application of hydrotropic solubilization in

the spectrophotometric estimation of frusemide in tabletsâ€, Pharma

Rev 2006;4:148.

Maheshwari RK. Chaturvedi SC, Jain NK. “Novel application of

hydrotropic solubilizing additives in the estimation of aspirin in bulk

sample and tabletsâ€, Int J Pharm Exc 2005;4:84.

Maheshwari RK. Chaturvedi SC, Jain NK. “Novel spectrophotometric

estimation of some poorly water soluble drugs using hydrotropic

solubilizing agentsâ€, Indian J Pharm Sci 2006;68:195.

Maheshwari RK. Chaturvedi SC, Jain NK. “Novel application of

hydrotropic solubilization in the quantitative analysis of some NSAIDs

and their solid dosage formsâ€, Indian J Pharm Sci 2007;69:101.

Maheshwari RK. Chaturvedi SC, Jain NK. “Application of hydrotropic

solubilization phenomenon in spectrophotometric analysis of

hydrochlorothiazide tabletsâ€, Indian Drugs 2005;42:541.

Maheshwari RK. Chaturvedi SC, Jain NK. “Application of hydrotropy in

spectrophotometric determination of pharmaceutical dosage formsâ€,

Indian Drugs 2005;42:760.

Jain NK, Agrawal RK, Singhai AK. Formulation of aqueous injection of

carbamazepine. Pharmazie 1990;45:221-2.

Darwish IA, Florence AT, Saleh AM. Effects of hydrotropic agents on

the solubility, precipitation, and protein binding of etoposide. J Pharm

Sci 1989;78:577-81.