Main Article Content
Interest exists in developing site-specific systems of release of drug in the colon via the oral route. Tegaserod maleate
was used as a drug for irritable bowel syndrome, whereas Eudragit L 100 and S100 mixture (1:1, 1:2, and 1:3) were
used as pH-sensitive polymers. Various approaches, namely microcapsules, compressed microcapsules, and modified tablets
were made for this study. The microcapsules were prepared by the emulsionâ€“solvent evaporation method using drug and
mixture of polymers. The prepared microcapsules were evaluated for various physicochemical parameters such as particle
size, surface morphology, drug loading capacity, and in vitro dissolution studies by half-dilution method employing various
pH environments (pH 1.2â€“6.8) for 24 hours. The batch prepared using the 1:2 drug polymer ratio was selected as an ideal
batch for compression to get the compressed tablet of the microcapsules. The compressed microcapsules were evaluated
for physicochemical parameters such as average weight, hardness, friability, thickness, and in vitro dissolution by the halfdilutionmethod.
The modified tablets were also prepared using the drug with hydroxylpropylmethylcellulose as the inner
material and ethyl cellulose as the outer material employing the double compression technique. The prepared tablets were
subjected to various physicochemical parameters, including thickness, weight variation test, drug content, hardness, friability,
and in vitro dissolution study using the half-dilution method (pH 1:2â€“6.8) for 24 hours. Comparisons of microcapsules,
compressed microcapsules, and modified tablets containing tegaserod maleate indicated that the drug release profiles from the microcapsules were found to be better than the compressed microcapsules and the modified tablets in the colonic environment.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Wakerly Z, Fell JT, Attwood D, Parkins DA. In vitro evaluation of pectinbased
colonic drug delivery system. Int J Pharm 1996;129:73-7.
Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted
drug delivery system. J Pharm Sci 2003;6:33-66.
Jain SK, Chourasia MK, Dengre R. Azopolymers for colon targeted drug
delivery. Indian J Pharm Sci 2005;67:43-50.
Nykanen P, Krogars K, Sakkinen M, Heinamaki J, Jurjensson H, Veski P,
et al. Organic acids as excipients in matrix granules for colon-specific
drug delivery. Int J Pharm 1999;184:251-61.
Sinha VR, Kumria R. Coating polymers for colon specific drug delivery:
A comparative in vitro evaluation. Acta Pharm 2003;53:41-7.
Ray S, Ghosh PK, Ghosh CK, Gupta BK. Statistical optimization
supported product development of anti-asthmatic multiparticulate
drug delivery system. Indian J Pharm Sci 2000;62:175-80.
Martin A. Physical Pharmacy, 4th ed. New Delhi: Wavery Pvt. Ltd; 1996.
Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. Microsphere
design for the colonic delivery of 5-fluorouracil. J Control Release
Lachman L, Liberman HA, Kanig JL. The theory and practice of industrial
pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1991. p. 297.
Basak SC, Sampath Kumar P, Manavalan R, Narendranath KA. Preparation
and evaluation of enteric coated pancreatin tablets. Indian J Pharm Sci
Sinha VR, Rachna K. Polysaccharides in colon specific drug delivery. Int
J Pharm 2001;224:19-38.
Koresmeyer RW, Gurny R, Doelkar E, Buri P, Peppas NA. Mechanisms
of solute release from porous hydrophilic polymers. Int J Pharm