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thereby reduce dosing frequency, improve patient compliance and reduce the doseâ€‘related sideâ€‘effects. Ranolazine is
indicated for the chronic treatment of angina in patients who have not achieved an adequate response with other antiâ€‘anginal
agent. The present investigation was undertaken to design the extended release tablets of ranolazine employing different
polymers as matrix forming agents using direct compression technique. Formulated tablets were evaluated for weight
variation, hardness, friability, drug content, swelling index and in vitro release studies. The drug release followed first order
kinetics and controlled by both erosion and diffusion mechanism. It is concluded that the desired drug release pattern can be obtained from the formulation containing 9.8% w/w eudragit and 39.2% w/w metallose offered relatively much slow release of ranolazine compared with other formulations. The selected formulation showed a similarity factor 76 when
comparing in vitro dissolution data of the commercial formulation ranozex 500.
Key words: Antiâ€‘anginal, diffusion mechanism, direct compression technique, matrix forming
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