Design and evaluation of the fast dissolving tablet of terbutaline sulfate
Main Article Content
aerosols and parenterals have a rapid onset of action but strongly affect the patient compliance.Thus, an attempt was made to improve the onset of action of bronchodilator used commonly in the treatment of asthma. Fast dissolving tablets of terbutaline sulfate were prepared by the direct compression method after incorporating superdisintegrants such as Explotab, Ac-Di-Sol and Polyplasdone XL in different concentrations.The prepared tablets were evaluated for weight variation, thickness, hardness, friability, wetting time, drug content, water absorption ratio, in vitro dispersion time, in vitro disintegration time and in vitro
drug release. Among all, the formulation F9 (containing 5% w/w concentration of Polyplasdone XL) was considered to be the best formulation, which releases up to 99.33% of the drug in 10 min.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Lindgren S, Janzon L. Dysphagia: Prevalence of swallowing complaints
and clinical finding. Med Clin North Am 1993;77:3-5.
Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral
drug delivery: A review. Pharm Sci Technol Today 2000;3:138-45.
Bradley JU, Lawrence ML. Drugs used in the treatment of
asthma. In: Hardman JG, Lee E, editors. Goodman and Gilmanâ€™s:
The Pharmacological basis of therapeutics. 10 th ed. New York:
The Mc Graw- ill Companies; 2001. p. 735.
Kucherkar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets of
salbutamol sulphate: A novel drug delivery system. Indian Drugs
Banker GS, Anderson NR. In: Lachman L, Liberman HA, Kanig JL,
editors. The theory and Practice of industrial pharmacy. 3rd ed. Mumbai:
Varghese Publishing House; 1987. p. 297.
Indian Pharmacopoeia. Vol. 2. Delhi: The Controller of Publications;
Arias MJ, Gines JM, Moyano JR, Perez-Martinez JI, Rabasco AM. Influence
of preparation method of solid dispersions on dissolution rate: Study
of triammterene-D- mannitol system. Int J Pharm 1995;123:25-31.
Yunxia B, Sunada H, Yonezawa Y, Danjo K. Evaluation of rapid
disintegrating tablets prepared by direct compression method. Drug
Dev Ind Pharm 1999;25:571.
Chaudhari PD, Chaudhari SP, Kolhe SR, Dave KV, More DM. Formulation
and evaluation of fast dissolving tablet of famotidine. Indian Drugs
Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J Pharm Edu