Enhancing Medication Solubility Using Nanosuspension: A Method
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Abstract
Its extremely low bioavailability is the main problem with poorly soluble medicines. The presence of medications
such as carbamazepine, simvastatin, and itraconazole – which are insoluble in both watery and non-aqueous
solutions and belong to the BCS class II of the pharmacological classification system – complicates matters even
more. Formulation as nanosuspension is a desirable and feasible answer to these problems. The drug is distributed
as a so-called nanosuspension, which is a pure, poorly water-soluble drug without any matrix components. The
simple synthesis of nanosuspensions can be advantageous for all drugs that are soluble in water. A nanosuspension
changes a drug’s pharmacokinetics, boosting safety and efficacy in addition to improving the drug’s soluble
condition and low bioavailability. The preparation techniques, article description, and review findings.
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