Enhancing Perphenazine Dissolution Profile through Innovative Solid Dispersion Techniques: A Comprehensive Study
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Abstract
Objective: Using the hydrophilic polymer polyethylene glycol 6000 (PEG 6000) and chitosan, the solid dispersion
(SD) technique is used to increase the solubility and dissolution of perphenazine. Materials and Methods: SDs of
perphenazine were prepared with polymers PEG 6000 and chitosan, using different methods of preparation: (1) Solvent
evaporation and (2) dropping technique method along with different drug: carrier ratios. Performance of the prepared
formulations was evaluated for solubility, Fourier transform infrared (FTIR) spectroscopy. Results: Perphenazine’s
solubility was improved in all SDs. Both solubility and carrier concentration were positively correlated. When prepared
using the dropping method, the concentration of the perphenazine- SD PPD2 1:2 demonstrated improved water solubility.
Conclusion: According to the investigations, PEG 6000 and chitosan later form an amorphous state in SD, which FTIR
confirms. The SD containing perphenazine (dropping method) demonstrated high solubility and drug release.
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