Development and Evaluations of NaturalGums-based Ranitidine HCL-loadedFloating Mucoadhesive Microspheres
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Abstract
Objective: Ranitidine hydrochloride (RH) is a commonly used antacid as an H2 receptor antagonist, which shows
the maximum absorption at the initial part of the small intestine. Moreover, colonic metabolism is also responsible
for poor oral drug bioavailability, which leads to a poor patient compliance. To improve therapeutic action and
patient compliance, it is required to design a formulation which can increase the retention of the drug into the
upper part of along with sustain release action. Thus, the aim of the present work was to investigate the role of
novel polysaccharides in combination in the development of floating mucoadhesive microspheres for localized drug
delivery of RH specifically into the upper parts of gastrointestinal tract. Materials and Methods: Ranitidine HCl
floating, mucoadhesive microspheres, were successfully developed by ionic gelation method. Results: The RBG3
was found to be best as it releases Ranitidine HCl 99.98 ± 0.25% at the end of 14 h in a sustained manner. It was stable
at 40°C/75% RH during accelerated stability studies carried out as per the International Council for Harmonization
guidelines. Conclusion: The floating mucoadhesive microspheres for localized drug delivery of RH were developed.
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