Comparative Evaluation of Two Natural Gelling Agents in Valdecoxib Emulgels Formulations
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Abstract
Introduction: In recent years, there has been great interest in the use of novel polymers with complex functions
as emulsifiers and thickeners because of the gelling capacity of stable emulsions. Emulgel for dermatological
use has several favorable properties, such as being thixotropic, greaseless, non-staining, easily spreadable, easily
removable, emollient, having a long shelf life, transparent, and pleasing appearance. Objectives: To develop
suitable topical gel formulations of valdecoxib using different gelling agents with permeation enhancers to reduce
adverse drug reactions associated with oral formulations. Materials and Methods: A total of six, i.e., F1–F6,
valdecoxib emulgel formulations were prepared using two different gelling agents in different concentrations, and
the prepared formulations were further evaluated for various parameters. Results: The formulation F3 showed the
overall best results. Valdecoxib emulgel formulations were successfully achieved.
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