Evaluating the Therapeutic Potentialof Lavender Aroma on Memory andBiochemical Alterations in an Amyloid-beta1-42 – Induced Dementia Model

Abstract

Objective: Neurodegenerative disorders, such as Alzheimer’s disease (AD), are progressive conditions that inflict
irreparable harm on neuronal structure and function. The research aimed to evaluate the impact of lavender essential
oil inhalation in an AD mouse model, and to examine the effects of donepezil in combination with essential oil
inhalation on olfactory impairments and cognitive decline. Methods: Animals were treated with lavender oil
(LO) aroma and donepezil, after which assessments of behavior, cognition, histology, and biochemical parameters
were conducted. Results: Animals administered amyloid-beta had considerable olfactory deficits, cognitive
impairment, neuronal degeneration, and neuroinflammation, with modified neurotransmitter concentrations.
Inhalation of LO, particularly at higher concentrations, markedly enhanced behavioral performance, memory
retention, neurotransmitter balance, and decreased neuroinflammatory markers. The combination of donepezil
and LO produced synergistic effects, showing greater neuroprotection, improved cognition, and enhanced
anti-inflammatory effects compared to individual treatments. Conclusion: This research effectively builds a
solid foundation for the olfactory involvement in the development of AD. Inhalation of lavender essential oil,
especially when combined with donepezil, is a potential supplementary approach for alleviating olfactory and
cognitive impairments associated with AD. Additional research is required to investigate the long-term safety and
effectiveness of essential oil inhalation in neurodegenerative disorders.