Stability Indicating Development and Validation of Ultraviolet Spectrophotometric Methods for the Simultaneous Estimation of Bromhexine and Cephalexin in their Combined Dosage Form

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Dr. K. Kiran Kumar

Abstract

Aim: The aim of this study is to develop two simple, rapid, accurate, economical validated spectrophotometric for simultaneous estimation of bromhexine and cephalexin in bulk and dosage form. Materials and Methods: The Method-I is first derivative spectrophotometric and Method-II is the simultaneous equation method. Both the methods were employed for the analysis of drugs bromhexine and cephalexin using methanol and ammonium hydrogen phosphate (pH 7.7) in the ratio of 60:40 as a diluent. Results and Discussions: Both the methods are used for the simultaneous determination of bromhexine and cephalexin at 2155 nm and 266.5 nm, respectively, over the concentration range of 0.2–1.2 μg/ml and 12.5–75 μg/ml with the correlation coefficient (r2) 0.9996 and 0.9994. Conclusions: The recovery studies confirmed the accuracy of proposed method and low-value standard deviation confirmed precession of method. The method is validated as per the International Council for Harmonization guidelines.

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How to Cite
Kumar, D. K. K. (2018). Stability Indicating Development and Validation of Ultraviolet Spectrophotometric Methods for the Simultaneous Estimation of Bromhexine and Cephalexin in their Combined Dosage Form. Asian Journal of Pharmaceutics (AJP), 11(04). https://doi.org/10.22377/ajp.v11i04.1741
Section
ORIGINAL ARTICLES