Transdermal drug delivery system: An overview
Main Article Content
condition, physicochemical factors and environmental factors are some factors that are to be considered while delivering drug through this route. Basic components ofÂ TDDS include polymer matrix, membrane, drug, penetration enhancers, pressure-sensitive adhesives, backing laminates, release liner, etc.Transdermal patches can be divided into various systems like reservoir
system, matrix system and micro-reservoir system, which are used to incorporate the active ingredients into the circulatory system via the skin.After preparation of transdermal patches, consistent methodology are adopted to test the adhesion properties,physicochemical properties, in vitro drug release studies, in vitro skin permeation studies, skin irritation studies and stability studies. According to the duration of therapy, various drugs are commercially available in the form of transdermal patches.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Tiwary AK, Sapra B, Jain S. Innovation in transdermal drug delivery:
Formulation and techniques. Recent Pat Drug Deliv Formul 2007;1:23-36.
Chong S, Fung HL, In: Hadgraft J, Guy RH, editors. Transdermal drug
delivery. development issues and research initiatives. New York: Marcel
Dekker; 1989. p. 135-54.
Singh A, Singh MP, Alam G, Patel R, Vishvakarma D, Datt N. Expanding
opportunities for transdermal delivery systems: An overview. J Pharm
Ansel HC, Allen LV and Popovich NG. Pharmaceutical dosage forms
and drug delivery system. 7th ed. New York: Lipponcott Williams and
Patel RP, Baria AH. Formulation and evaluation consideration of
transdermal drug delivery system. Int J Pharm Res 2011;3:1-9.
Kumar JA, Pullakandam N, Prabu SL, Gopal V. Transdermal drug delivery system: An overview. Int J Pharm Sci Rev Res 2010;3:49-54.
Jain NK. Advances in controlled and novel drug delivery. 1st ed.
New Delhi: CBS Publishers and Distributors; 2001. p. 108-10.
Soni M, Kumar S, Gupta GD. Transdermal drug delivery: A novel
approach to skin permeation. J Pharm Res 2009;2:1184-90.
Naik A, Kalia YN, Guy RH. Transdermal drug delivery: Overcoming the
skinâ€™s barrier function. Pharm Sci Technol Today 2009;3:318-26.
Chandrashekhar NS, Shobha R. Physicochemical and pharmacokinetic
parameters in drug selection and loading for transdermal drug delivery.
Indian J Pharm Sci 2008;70:94-5.
Merkle HP. Transdermal delivery systems. Methods Find Exp Clin
Brown L and Langer R. Transdermal delivery of drugs. Annu Rev Med
Arunachalam A, Karthikeyan M, Kumar DV, Prathap M, Sethuram S,
Kumar AS. Transdermal drug delivery system: A review. Curr Pharma
Flynn GL. Percutaneous Absorption. 3rd ed. New York: Marcel Dekker;
Hadgraft J. Skin Deep. Eur J Pharm Biopharm 2004;58:291-9.
Singh MC, Naik AS, Sawant SD. Transdermal drug delivery systems
with major emphasis on Transdermal Patches: A review. J Pharm Res
Aulton ME. Aultonâ€™s Pharmaceutics The design and manufacture of
medicine. 3rd ed. Churchill Livingstone: Elsevier; 2007. p. 567-8.
Jain NK. Controlled and Novel Drug Delivery. New Delhi: CBS Publishers and Distributors; 2002. p. 107.
Kumar TS, Selvam RP, Singh AK. Transdermal drug delivery systems for antihypertensive drugs. Int J Pharm Biomed Res 2010;1:1-8.
Chien YW. Novel drug delivery systems, Drugs and the Pharmaceutical
Sciences, Vol. 50. New York: Marcel Dekker; 1992. p. 797.
Sugibayashi K, Morimoto Y. Polymers for transdermal drug delivery
systems. J Control Release 1994;29:177-85.
Hadgraft J, Guy RH. Transdermal Drug Delivery. 2nd ed. New York:
Marcel Dekker; 1989.
Keleb E, Sharma RK, Mosa EB, Aljahwi A. Transdermal drug delivery
system and evaluation. Int J Adv Pharm Sci 2010;1:201-11.
Spencer TS, Smith SE, Conjeevaram S. Adhesive interactions between
polymers and skin in transdermal delivery systems. Polym Mater: Sci
Minghetti P, Cilurzo F, Tosi L, Casiraghi A, Montanari L. Design of a new
water-soluble pressure-sensitive adhesive for patch preparation. AAPS
Pharm Sci Tech 2003;4:9.
Tyle P. Drug Delivery device. 3rd ed. New York and Basel: Marcel Dekker;
Pfister WR, Sieh DS. Permeation Enhancer compatible with transdermal
drug delivery systems. Part I: Selection and Formulation consideration.
Med Device Technol 1990;1:48-55.
Godbey KJ. Improving patient comfort with non-occlusive transdermal
backings. AAPS Pharm Sci Tech 1996;1-2.
Walters KA. Transdermal drug delivery system In: Swarbick K, Boylan JC, editors. Encyclopedia of Pharmaceutical Technology. New York: Marcel Dekker; 1997. p. 253-93.
Foco A, Hadziabdic J, Becic F. Transdermal Drug Delivery Systems. MedArch 2004;58:230-4.
Sakalle P, Dwivedi S, Dwivedi A. Design, evaluation, parameters and
marketed products of transdermal patches: A review. J Pharm Res
Brahmankar DM, Jaiswal SB. Biopharmaceutics and pharmacokinetics
A treatise. Delhi: Vallabh Prakashan; 1995. p. 335-71.