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the drugs where a constant drug release, i.e., a zero-order release is not desired. Pulsatile drug delivery system is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-release period, i.e., lag time. Various systems like capsular systems, osmotic systems, pulsatile system based on the use of
soluble or erodible polymer coating, use of rupturable membranes and pulsatile system based on membrane permeability are summarized in this article.These systems are beneficial for the drugs having chronopharmacological behavior where night timeÂ dosing is required and for the drugs having high first-pass effect and having specific site of absorption in gastrointestinal tract.
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Kikuchi A, Okano T. Pulsatile drug release control using hydrogels. Adv
Drug Deliv Rev 2002;54:53-77.
Rubinstein A, Tirosh B, Baluom M, Nassar T, David A. The rationale
for peptide drug delivery to the colon and the potential of polymeric
carriers as effective tools. J Controlled Release 1995;46:59-73.
Youan BC. Chronopharmaceutics: Gimmick or clinically relevant
approach to drug delivery. J Controlled Release 2004;98:337-53.
Baichwal, Anand R. Woodcook US20050276853, 2005.
Krogel I, Bodmeir R. Pulsatile drug release from an insoluble capsule
body controlled by erodible plug. Pharm Res 1998;15:474-81.
Krogel I, Bodmeir R. Evaluation of enzyme-containing capsular shaped
pulsatile drug delivery system. Pharm Res 1999;19:1424-9.
Krogel I, Bodmeir R. Development of multifunctional matrix drug
delivery system surrounded by an impermeable cylinder. J Controlled
Percel P, Vishnupad KS, Venkatesh GM. US20036627223B2 2003.
Barzegar-Jalali M, Siyahi-Shadbad M. Design and evaluation of delayed-
release osmotic capsule of acetaminophen. Iran J Pharma Sci Spring
Linkwitz A, Magruder JA, Merrill S. US5318558, 1994.
Niwa K, Takaya T, Morimoto T, Takada K. Preparation and evaluation
of time controlled release capsule made of ethyl cellulose for colon
delivery of drugs. J Drug Targeting 1995;3:83-9.
Maroni A, Zema L, Cerea M, Sangalli ME. Oral pulsatile drug delivery
systems. Exp Opin Drug Deliv 2005;2:855-71.
Conte U, Arsizio B, Manna AL, Comolobo P. US4865849.
Pozzi F, Furlani P, Gazzaniga A, Davis SS. The TIME CLOCK system:
A new oral dosage form for fast and complete release of drug after
predetermined lag time. J Controlled Release 1994;31:99-108.
Fan TY, Wei SL, Yan W. An investigation of pulsatile release tables with
ethylcellulose and Eudrajit L as film coating materials and crosslinked
polyvinyl pyrrolidone in the core tablets. J Controlled Release
Barr IG, Thiel WJ. US5593697.
Bussemer T, Dashevsky A, Bodimeir R. A pulsatile drug delivery system
based on rupturable coated hard gelatin capsules. J Controlled Release
Chen CM. US5260068.
Chen CM. US5508040.