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meloxicam. PEG 6000, PEG 8000, PEG 20000, Lutrol F-127, and Î²-cyclodextrin were selected for the preparation of SD. The SDs were prepared by melting and solvent evaporation methods. Dissolution studies were performed for plain
meloxicam, SDs, and tablet formulations. Infrared spectroscopy and differential scanning calorimetry were performed to identify the physicochemical interaction between drug and carriers. Dispersible tablets and effervescent tablets were
compared with tablet containing plane drug for dissolution profile. Dissolution of DT improved significantly in SD product
(<95% in 1 min).
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Fleischmann R, Iqbal R, Slobodin G. Meloxicam. Exp Opin Pharmacother
EI-Badry M, Fathy M. Enhancement of dissolution and permeation
rates of Meloxicam by formation of its Freeze-dried solid dispersion
in polyvinyl pyrrolidone K-30. Drug Dev Ind Pharm 2006;32:141-2.
Betageri GV, Makarla. Enhancement of dissolution of glyburide by solid
dispersion and lyophilization techniques. Int J Pharm 1995;126:155-60.
Hajratwala BR. Dissolution of solid dispersion systems. Aust J Pharm
Chio WL, Riegelman S. Pharmaceutical application of solid dispersion
system. J Pharm Sci 1971;60:1281-302.
El-Gazayerly ON. Characterization and evaluation of tenoxicam
coprecipitates. Drug Dev Ind Pharm 2000;26:925-30.
Karanth K, Shenoy VS, Murthy RR. Industrially feasible alternative
approaches in the manufacture of solid dispersion: A technical report.
AAPS Pharma Sci Tech 2006;7:1-7.
Higuchi T, Connors KA. Phase-solubility techniques. Adv Anal Chem