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an attempt was made to mask the taste and to formulate into a oro-dispersible tablet by complexation with ion exchange resins, which also acts as super disintegrating agents. Since, these tablets can be swallowed in the form of dispersion, it is suitable dosage form for pediatric and geriatric patients. Cation exchange resins like Indion-204 and Indion-234 were utilized for the sorption of drug. Drug-resinates were prepared in drug to resin ratio of 1:5 and 1:6. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, taste evaluation, mouth feel, wetting time, in vitro and in vivo disintegration time, and in vitro dissolution studies. Tablets with both the resins have shown quick disintegrating features, i.e., within 20 s, which is very characteristic of oro-dispersible tablets. Also, the dispersion not showing any bitter taste, indicate the capability of ion exchange resins used, both as taste masking and super disintegrating agents. Almost more than 90 percent of drug was released from both the formulations within 1 h. Further formulations were subjected to stability testing for 3 months at temperatures 25Â±5oC/60Â±5%RH and 40Â±5oC/75Â±5%RH. Both tablets have shown no appreciable changes with respect to taste, disintegration, and dissolution profiles.
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Lachman, Liberman HA, Anig JL. Theory and practice of industrial
pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1991. p.
Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A, Iida K. Preparation
and evaluation of a compressed tablet rapidly disintegrating in the
oral cavity. Chem Pharm Bull (Tokyo) 1996;44:2121-7.
Indian pharmacopoeia, Govt of India, ministry of health and family
welfare. New Delhi: The Controller of Publications; 1996. Appendix
Wen, Betty, Ramsay, Michael P, Scheurer, Hein Rich Dokuzovic, et
al. Antussive drugs delivered by ion exchange resins. U.S patent
Kohli DP, Shan DH. Drug formulation manual. Eastern Publishers;
Avari JG, Bhalekar M. Cation exchange resin for taste masking and
rapid dissolution of Sparfloxacin. Indian Drugs 2003;4:19-23.
Hiremath JG, Shastry CS, Srinath MS. Pharmaceutical approaches of
taste masking in oral dorage forms. Indian Drugs 2004;41:253-7.
Tripati KD. Essentials of medical pharmacology. 5th ed. New Delhi:
Jaypee Brothers Medical Publisher; 2003. p. 196.
Chaudhari PD, Chaudhari SP, Lanke SD, Patel N. Formulation and
in vitro evaluation of taste masked orodispersible dosage form of
Levocetirizine. Indian J Pharm Educ Res 2007;41:319-28.
Chatap VK, Sharma DK, Middha A, Gupta RD, Saini V, Shiradkar M, et
al. Mouth disintegrating tablets of taste-masked ondansetron HCl.
Asian J Chem 2007;19:3455-60.9.
Available from: http://www.venpetro.com/Ambroxol hydrochloride.
RO - CEP 2004-240-Rev 00. htm
Sayed MS, Ulviya G, Bajaj AN. Oral controlled release Bromohexine
ion exchange resinate suspension formulation. Indian Drugs
Nanda AR, Kandarapu, Garg S. An update on taste masking technologies for oral pharmaceuticals. Indian J Pharm Sci 2002;64:10-7.
Geetha Rao CG, Motiwale AV, Satyanarayana D, Subrahmanyam EV.
Formulation of taste masked oral suspension of quinine sulphate by
complexation. Indian J Pharm Sci 2004;66:329.