Main Article Content
microspheres were prepared by emulsification cross-linking method. Microspheres were characterized for entrapment efficiency, particle size, in-vitro drug release and surface morphology was studied by scanning electron microscopy. The
entrapment efficiency of the glutaraldehyde and formaldehyde cross-linked microspheres was significantly higher (P<0.05) than the heat-cross-linked microspheres. In-vitro drug release studies indicated that the microspheres cross-linked using glutaraldehyde showed slower release rate than those cross-linked with formaldehyde while the heat cross-linked microspheres showed the fastest release.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Shin Y, Yoo DI, Min K. Antimicrobial finishing of polypropylene non-
woven fabric by treatment with chitosan oligomer. J Appl Polymer Sci
Miyazaki S, Yamaguchi H, Yokouchi C, Takada M, Hou WM. Sustained-
release and intragastric-floating granules of indomethacin using
chitosan in rabbits. Chem Pharm Bull (Tokyo) 1988;36:4033-8.
Thachrodi D, Rao KP. Development and in-vitro evaluation of chitosan-
based transdermal drug delivery systems for the controlled delivery of
propanolol hydrochloride. Biomaterials 1995;16:145-8.
Upadrashta SM, Katikaneni PR, Nuessle NO. Chitosan as a tablet binder.
Drug Dev Ind Pharm 1992;18:1701-8.
Chandy T, Sharma CP. Chitosan beads and granules for oral sustained
delivery of nifedipine: In-vitro studies. Biomaterials 1992;13:949-52.
Chandy T, Sharma CP. Effect of liposome-albumin coatings on
ferric ion retention and release from chitosan beads. Biomaterials
Akbuga J, Bergisadi N. Effect of formulation variables on cis-platin loaded chitosan microsphere properties. J Microencapsul 1999;16:697-703.
Aggarwal A, Kaur S, Tiwary AK, Gupta S. Chitosan microspheres
prepared by an aqueous process: Release of indomethacin. J.
Denkbas EB, Seyyal M, Piskin E. 5-Fluorouracil loaded chitosan
microspheres for chemoembolization. J Microencapsul 1999;16:
Kumbhar SG, Kulkarni AR, Aminabhavi M. Cross-linked chitosan
microspheres for encapsulation of diclofenac sodium: Effect of cross-
linking agent. J Microencapsulation 2002;19:173-80.
Hassan EE, Parish RC, Gallo JM. Optimized formulation of magnetic
chitosan microspheres containing the anticancer drug, oxantrazole.
Pharm Res 1992;9:390-7.
Thanoo BC, Sunny MC, Jayakrishnan A. Cross-linked chitosan
microspheres: Preparation and evaluation as a matrix for the controlled
release of pharmaceuticals. J Pharm Pharmacol 1992;44:283-6.
Ohya Y, Takei T, Kobayashi H, Ouchi T. Release behaviour of 5-fluorouracil from chitosan gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition. J
Akbuga J, Durmaz G. Preparation and evaluation of cross-linked chitosan microspheres containing furosamide. Int J Pharm 1994;111:217-22.
Jameela SR, Kumary TV, Lal AV, Jayakrishnan A. Progesterone loaded
chitosan microspheres: A long acting biodegradable controlled delivery
system. J Controlled Release 1998;52:17-24.
Genta I, Perugini P, Conti B, Pavenetto F. A multiple emulsion method
to entrap lipophilic compound into chitosan microspheres. Int J Pharm
Genta I, Conti B, Perugini P, Pavanetto F, Spadaro A, Puglisi G.
Bioadhesive microspheres for ophthalmic administration of acyclovir.
J Pharm Pharmacol 1997;49:737-42.
Lim LY, Wan LS. Heat treatment of chitosan films. Drug Dev Ind Pharm