Psoriasis is a chronic inflammatory disease influencing 1â€“3% of the all-inclusive community with significant hindrance to personal quality of life. These conditions may adversely influence the patientâ€™s quality of life and prompt psychosocial stretch. Psoriasis can be arranged as mild, moderate, and severe conditions. Mild psoriasis prompts the formation of rashes, and when it ends up moderate, the skin transforms into scaly. It is important to control and limit the indications of psoriasis to give patient long-lasting protection since psoriasis is not presently curable yet it can go into reduction, creating a normal/ordinary skin surface. Customary conventional treatments for psoriasis are utilized for the treatment of incorporate topical, oral, or systemic formulation yet have a potential for long-term danger and may not generally give adequate change of the illness. Dermal treatment guaranteeing percutaneous penetration is presently very suggested in topical signs for psoriatic patients, which can be accomplished utilizing pharmaceutical nanotransporters nanovesicle and nanoparticle and so forth. The advancement of novel treatments focusing on the pathogenesis of psoriasis presently gives new and efficient treatment alternatives such as nanoparticulate/nanovesicular gels, which are more powerful in diminishment of purities, scaling, and hyperkeratosis of psoriasis plaque. Because of high drug loading, productivity, and stability, novel transporter diminishes the scaly patches and decreases of humoral immunity. Point of the survey is to center around the effect of nanotechnology construct drug delivery approaches in light of different anti-psoriasis drugs delivery for the fruitful treatment of psoriasis with negligible poisonous or toxic response.