Spectrophotometric determination of nateglinide in bulk and tablet dosage forms
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dosage forms have been developed. In method I, methanol-AR was used as solvent, while in method II, Methanolâ€AR + 10% V/V 3N NaOH was used as reference solvent. In method I, nateglinide shows Î»max at 216 nm, which is then shifted to 225.4 nm on increasing the basicity of the reference solvent in method II.The linearity for nateglinide was observed to be statistically in
the range of 10-100 Î¼g/ml in method I and 100-1000 Î¼g/ml in method II. Both the methods were validated using ANOVA. The recovery studies confirmed the accuracy of the proposed methods.
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