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floating properties (floating lag time, floating time and matrix integrity), swelling studiesÂ and drug content. The physicochemical parameters of formulated tablets were found to be within normal range. A significant difference in drug
release (P , 0.0001) and floating lag time (P , 0.005) at 0.5, one, four and eight hours were observed. The floating lag time of all the formulations was within the prescribed limit (,10 minutes). All the formulations showed good matrix
integrity and retarded the release of drug for eight hours. The release pattern of atenolol was fitted to different models based on coefficient of correlation (r). All the formulations, except F2, F3 and F6 showed Korsemeyer-Peppas model
as the best fit model. Formulation F2 and F3 showed first order model while F6 showed zero order model. Diffusion exponent (n) value was found in the range of 0.52-0.99 indicating diffusion as a release mechanism. The swelling studies
of all the formulations showed that formulations containing Xanthan gum has higher swelling indices than HPMC K100M and HPMC K4M. It can be concluded that formulations with higher swelling indices retarded the release of drugs more
than those with lower swelling indices.
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