Preparation and evaluation of sweet potato starch-blended sodium alginate microbeads

Main Article Content

Antesh K Jha
A Bhattacharya

Abstract

The design of effective drug delivery systems has recently become an integral part of the development of new medicines. Hence, research continuously keeps searching for ways to deliver drugs over an extended period of time with
a well-  ontrolled release profile.The ionotropic gelation method was used to prepare sweet potato starch-blended controlledc
release alginate microbeads of ibuprofen. Sweet potato is an important crop in  many developing countries. Although sweet potato originated from Central America, its ability to adapt to a wide variety of climatic conditions allows it to grow both in tropical and in moderate temperature regions of Africa, Asia and the Americas. The influence of various formulation factors such as in vitro drug release, entrapment efficiency, swelling study and micrometric properties was investigated. Other variables included sweet potato starch concentration, percentage drug loading, curing time, cross-linking agent and stirring speed during
the microencapsulation process. The entrapment efficiencies were found in the range of 71.85 ± 2.04 - 94.53 ± 1.02%. The particle sizes were found in the range of 0.82 ± 0.006 - 1.08 ± 0.009 mm. This suggested that the ionotropic gelation method was successful in producing sweet potato starch-blended alginate microbeads.

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How to Cite
Jha, A. K., & Bhattacharya, A. (2014). Preparation and evaluation of sweet potato starch-blended sodium alginate microbeads. Asian Journal of Pharmaceutics (AJP), 3(4). https://doi.org/10.22377/ajp.v3i4.283
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References

Woolfe JA. Sweet potato: An untapped food resource. Cambridge:

Cambridge University Press; 1992. p. 1-5.

Tian SJ, Rickard JE, Blanshard JM. Physicochemical properties of sweet

potato starch. J Sci Food Agr 1991;57:459-91.

Hoover R. Composition, molecular structure, and physicochemical

properties of tuber and root starches: A review. Carbohydrate Polymer

;45:253-67.

Takeda Y, Hizukuri S, Takeda C, Suzuki A. Structure of branched

molecules of amylose of various origins and molar fractions of branched

and unbranched molecules. Carbohydrate Reserves 1987;165:139-45.

Rasper V. Investigations on starches from major starch crops grown

in Ghana. II Swelling and solubility patterns and amyloelastic

susceptibility. J Sci Food Agr 1969;20:642-6.

Delpeuch F, Favier JC. Characteristics of starches from tropical food

plants: Alpha amylose hydrolysis swelling and solubility patterns. Ann

Technol Agr 1980;29:53-67.

Takeda Y, Takunaga N, Takeda C, Hizukuri S. Physicochemical properties

of sweet potato starches. Starch/Stärke 1986;38:345.

Zobel HF. Molecules to granules: A comprehensive starch review.

Starch/ Stärke 1988a;40:44-50.

Garcia AM, Walter WM Jr. Physicochemical characterization of starch

from Peruvian sweet potato selections. Starch/Starke 1998;50:331-7.

Collado LS, Mabesa RC, Corke H. Genetic variation in the physical

properties of sweet potato starch. J Agr Food Chem 1999;47:4195-201.

Del Rosario RR, Pontiveros CR. Retrogradation of some starch mixtures. Starch/Stärke 1983;35:86-92.

Smidsrod O, Skjak-Braek G. Alginate as an immobilization matrix for

cells. Trends Biotechnol 1990;8:71-8.

Rasenack N, Muller BW. Ibuprofen crystals with optimized properties.

Int J Pharma 2002;245:9-24.

Filippo PG, Lovato D, Martelli S. New controlled-release ibuprofen

tablets. Drug Dev Industrial Pharma 1999;25:671-7.

Cox PJ, Khan KA, Munday DL, Sujja-areevath J. Development and

evaluation of a multiple-unit oral sustained release dosage form

for S (þ)-ibuprofen: Preparation and release kinetics. Int J Pharma

;193:73-84.

Majid Khan G, Zhu JB. Formulation and in vitro evaluation of

ibuprofenâ€carbopol 974P-NF controlled release matrix tablets III:

Influence of co-excipients release rate of the drug. J Control Release

a;54:185-90.

Majid Khan G, Zhu JB. Ibuprofen release kenetics from controlledâ€release tablets granulated with aqueous polymeric dispersion of ethylcellulose II: Influence of several parameters and coexcipients. J Control Release 1998b;56:127-34.

Majid Khan G, Zhu JB. Studies on drug kinetics from ibuprofen-carbomer hydrophilic matrix tablets: Influence of co-excipients on release rate of the drug. J Control Release 1999;57:197-203.

Paavola A, Yliruusi J, Rosenberg P. Controlled release of lidocaine and

ibuprofen from injectable poloxmer-based gels. J Control Release

;52:169-78.

Paavola A, Kilpelainen I, Yliruusi J, Rosenberg P. Controlled release

injectable liposomal gel of ibuprofen for epidural analgesia. Int J Pharma

;199:85-93.

Ozdemir N, Sahin J. Design of a controlled release osmotic pump system of ibupofen. Int J Pharma 1997;158:91-7.

Sipahigil O, Dortunc B. Preparation and in vitro evaluation of verapamil

HCl and ibuprofen containing carrageenan beads. Int J Pharma

;228:119-28.

Kachrimanis K, Ktistis G, Malamataris S. Crystallisation conditions and

physicomechanical properties of ibuprofen-Eudragit S100 spherical

crystal agglomerates prepared by the solvent-change technique. Int

J Pharma 1998;173:61-74.

Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Hollow microspheres

for use as a floating controlled drug delivery system in the stomach.

J Pharma Sci 1992;81:135-40.

Gallardo A, Eguiburu JL, Jose, Fernandez Berridi M, Roman JS.

Preparation and in vitro release studies of ibuprofen-loaded films and

microspheres made from graft copolymers of poly (L-lactic acid) on

acrylic backbones. J Control Release 1998;55:171-9.

Perumal D, Dangor CM, Alcock RS, Hurbans N, Moopanar KR. Effect of

formulation variables on in vitro release and micromeritic properties

of modified release ibuprofen microspheres. J Microencapsulation

;16:475-87.

Tamilvanan S, Sa B. Studies on the in vitro release characteristics of

ibuprofen-loaded polystyrene microparticles. J Microencapsulation

;17:57-67.

Pignatello R, Bucolo C, Ferrara P. Eudragit RS. 100 nanosuspensions

for the ophthalmic controlled delivery of ibuprofen. Eur J Pharma

Biopharma Sci 2002;16:53-61.

Leo E, Forni F, Bernabei MT. Surface drug removal from ibuprofen-loaded PLA microspheres. Int J Pharma 2000;196:1-9.

Arica B, Calis S, Atilla P, Durlu NT, Cakar N, Kas HS, et al. In vitro and

in vivo studies of ibuprofen-loaded biodegradable alginate beads.

J Microencapsulation 2005;22:153-65.

Lee DW, Hwang SJ, Park JB, Park HJ. Preparation and release

characteristics of polymer- coated and blended alginate microspheres.

J Microencapsulation 2003;20:179-92.