Main Article Content
variables such as stirring speed, temperature of the medium, drug polymer ratio and ratio of light liquid paraffin and heavy liquid paraffin, maximum encapsulation efficiency was obtained. These microspheres were free-flowing in nature, discrete and uniform spherical in size, as evident by scanning electron microscopy. The in vitro release experiments were carried out in the simulated intestinal fluid (pH 7.2 phosphate buffer) using united States Pharmacopoeia (USP) XXII apparatus II. The data obtained from the dissolution profiles were compared using different kinetics models and the regression coefficients
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Bianco D, Hardy RM. Treatment of Evansâ€™ syndrome with human
intravenous immunoglobulin and leflunomide in a diabetic dog.
J Am Anim Hosp Assoc 2009;45:147-50.
Jacckson RL, Morrow JD. Analgesic-antiptretic and antiinflammatory
agents and treatment of gout. In: Joel GH, Lee EL, editors. Goodman
and Gilmanâ€™s The Pharmacological Basis of Therapeutics, 11th ed.
New Delhi: McGraw Hill; 2005. p. 1415.
Bhalerao SS, Lalla JK, Rane MS. A study of electro kinetic and stability
property of suspension of diltiazem hydrochloride micro spheres.
Indian Drugs 2001;38:464-7.
Yeo Y, Park K. Characterization of reservoir-type microcapsules made
by the solvent exchange method. AAPS Pharmscitech 2004;5:52.
Fery A, Dubreuil F, Mohwal H. Mechanics of artificial microcapsules.
New J. Phys. Doi:10.1088/1367-2630/6/1/018.
Trapani A, Laquintana V, Denora N, Lopedota A, Cutrignelli A, Franco M,
et al. Eudragit RS. 100 microparticles containing 2-hydroxypropyl-b-
cyclodextrin and glutathione: Physicochemical characterization, drug
release and transport studies. Eur J Pharma Sci 2007;30:64-74.
Tirosh B, Baluom M, Nassar T, Friedman M, Abraham R. The effect of
Eudragit RL-100 on the mechanical and mucoadhesion properties of
polycarbophil dosage forms. J Control Release 2007;45:57-64.
Basu SK, Adhiyaman R. Preparation and characterization of
nitrendipineâ€loaded Eudragit RL 100 microspheres prepared by an
emulsion-solvent evaporation. Trop J Pharma Res 2008;7:1033-41.
Chowdary KP, Ramesh KV. Studies on micro capsulation of diltiazem.
J Pharm Sci 1993;55:52-4.
Baidya S, Bedi S, Gupta BK. Design and evaluation of microcapsules of
diltiazem hydrochlodide. Boll Chim Farmac Anno 2001;14:l.
USPXXII. The United States Pharmacopoeia, United States Pharma
copoeia Convention INC. Rockville:2002. p. 449.