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active components of antihypertensive drug formulations (enalapril maleate + amlodipine besilate and
ramipril 1 hydrochlorothiazide) on high-performance liquid chromatography (HPLC) and thin layer chromatography.
The mobile phase consists of methanolâ€“water (60:40 v/v) for reversed-phase thin layer chromatography (RPTLC). Detection
was carried out by iodine vapors. The HPLC method was developed on a C-18 column with detection carried out by a UV
detector at 215 and 220 nm for enalapril maleate 1 amlodipine besilate and ramipril + hydrochlorothiazide, respectively.
The HPLC method was validated using data elements specificity, linearity and range, and accuracy and precision.
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