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Objectives: This study aimed to improve and assess the transdermal of folic acid through the skin through
non-ionic microemulsions (MEs). Methods and Instruments: Eight MEs were developed with different ratios
of Span 20-to-Tween 80 and folic acid contents. These MEs were characterized for their droplet sizes, rheological
properties. Besides, the encapsulation of folic acid insides the MEs was studied using Fourier-transform infrared
spectroscopy. Furthermore, the flux of formulated folic acid in MEs was evaluated using Franz diffusion cell.
Results: The MEs showed Newtonian viscosity and droplets sizes <200 nm. However, the droplets sizes
increased with increasing Tween 80 and folic acid content. Furthermore, the flux of folic acid related to folic
acid concentration. However, using MEs, a high flux of 11.47 Â± 6.9 Ã— 10âˆ’4 Î¼g/cm2 Ã— h of folic acid through ratâ€™s
skin could be achieved. Conclusion: The developed non-ionic MEs containing folic acid can be ideal carriers for
administration of folic acid transdermally.
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