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gastroretentive delivery using 23 factorial design. The effects of xanthan gum, guar gum, carbopol 934 P as hydrophilic
polymerâ€‘blends on drug release were analyzed. The optimized tablets were floated well in simulated gastric fluid (SGF)
(>8 h) with no lagâ€‘time and also showed a good bioadhesion time (5.23 Â± 0.25 min) on goat intestinal mucosa in SGF.
The in vitro drug release of these tablets showed sustained ondansetron HCl release over 8 h, which correlated well with
controlledâ€‘release (zero order) pattern with super caseâ€‘II transport mechanism.
Key words: Bioadhesion, floatation, gastroretention, matrix tablets, ondansetron HCl, polymerâ€‘blend
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