Procyanidin B2 of Cassia fistula a Potent Inhibitor of COVID19 Protease: A Molecular Dynamic Simulation Analysis

Dr. Lokesh Ravi


Based on molecular dynamic simulation studies and “Siddha” medicinal practice, this study proposes that, Cassia
fistula fruit pulp consists of procyanidin B2, which is a potential protease inhibitor that can be used for the
treatment of COVID19 infection. Virtual drug screening method and MD simulation were used to analyze 430
phytochemicals of 20 ethnobotanical medicinal plants suggested by Siddha medicine practitioner as antiviral
sources and treats symptoms related to COVID19. MD simulation strongly suggested that procyanidin B2 exhibits
strong protease inhibition potential, better than the co-crystallized reference ligand O6K. Scientific evidence states
that C. fistula exhibits significant antiviral activity against human viral infections in addition to other medicinal
activities. The fruit pulp of C. fistula is a readily market available product that can significantly aid in recovering
the COVID19 infected patients from complications. It is proposed to the research centers and clinics that are
currently treating the COVID19 patients to make an attempt to use the C. fistula fruit pulp as a hot water extract
to improve the patient’s response and prevent further mortalities due to the same.

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