Preparation and Assessment of Clomiphene Citrate Liquisolid Tablets for Solubility Enhancement

Prajitha Biju


Introduction: Clomiphene citrate is a nonsteroidal ovulation inducer used in the treatment of infertility. This drug
belongs to biopharmaceutical classification system Class-II often possesses challenges concerning solubility or
poor dissolution, drug release, and thereby enhance the bioavailability. Aim: The aim of the study was to improve
the solubility of the drug as well as to make the formulation more feasible liquisolid technique was adopted.
Materials and Methods: Here, Avicel PH 102(Q) and Aerosil 200(q) in varying ratios ranging from 5, 10, 20,
and 25 were employed as coating and carrier materials (R=Q/q), and their quantities incorporated into formulation
were calculated based on the mathematical formulae developed by Spireas and final powder substrate developed
was compressed into a tablet by direct compression method. Twelve formulations LS1 to LS12 were prepared and
subjected to drug excipient interactions studies, pre-compression, and post-compression studies and compared
with the marketed formulation. Results and Discussion: The Fourier transform infrared spectroscopy results
showed no interaction between drug-excipients. Scanning electron microscopy and X-ray diffractometry analysis
indicated that the clomiphene citrate is held within the powder substrate in a solubilized, almost molecularly
dispersed state and in liquisolid as an amorphous powder with no signs of instability on storage. An optimized
formulation was selected based on the in vitro, drug release studies. LS2 formulation containing Avicel PH
102(Q):Aerosil 200(q) a ratio of 10:1 and drug concentration 10% exhibited the controlled and complete/highest
drug release rate of 96.46% in 30 min in comparison with the marketed product. Conclusion: Thus, we propose
that liquisolid technique can be chosen as the most economical and alternative approach to enhance the solubility
of clomiphene citrate.

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