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Aim: The aim of the study was to evaluate the potential synergistic effect of natural and thermally modified
starch blends from maize and potato. Materials and Methods: The maize and potato starches were combined
in proportions of 1:1 (NSB1) and 1:2 (NSB2) and thermally treated (pregelatinization and retrogradation). For
their application as excipients, these thermally treated starch blends were compared to natural starch blends for
physicochemical parameters such as moisture content, water holding capacity, swelling and solubility, and amylose
concentration. Results and Discussion: The amylose content of the heat-treated gums increased, indicating that it
could be used in colon medication administration. The increase in water holding capacity from 218.13 Â± 0.13% to
732.27 Â± 0.34% demonstrates its promise in hydrogel creation. The moisture percentage of all the blends was in
the range of 10.10 Â± 0.03%â€“15.42 Â± 0.03%, which were well within the range specified in Indian Pharmacopoeia.
All of the samplesâ€™ pH levels were determined to be mildly basic (7.15â€“7.46). Conclusion: The potato and maize
modified starch blends demonstrated a promising synergistic impact compared to native blends as an adjuvant in
the formulation of various drug delivery systems.
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