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Coâ€crystal chemistry has recently attracted supramolecular scientists. Coâ€crystals are comprising of hydrogen boding
assembly between different molecules. Many issues related to performance characteristics of an active pharmaceuticalÂ ingredient (API) can be resolved using coâ€crystallization approach. Proper understanding of crystal structure of an API isÂ required for successful formation of coâ€crystals with the selected coâ€former. This review article focus on explanation aboutÂ coâ€crystals, intellectual property rights, their advantages and limitations. Coâ€crystallization can be achieved using differentÂ methods like coâ€grinding slurry based, solvent evaporation method, etc. Methods of coâ€crystallization are simple andÂ increase the purity of the final product. Coâ€crystallization can be applied to the drugs prescribed in combination therapy.Â Stoichiometric composition of different drugs used in combination therapy can be coâ€crystallize to form one solid state form.Â Physicochemical properties of APIs such as solubility and stability can be improved using coâ€crystallization approach. WithÂ due regards coâ€crystallization should be used with caution because of some issues during manufacturing of final product.
Key words: Chiral switch, crystal engineering, hydrogen bonding, intellectual property rights, polymorphism
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