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Introduction: Vilsmeier-Haack (VH) reactions are mostly too slow even at higher temperatures.
However, quick and easy transformation was observed in micellar media even at moderate temperatures.
Materials and Methods: Different types of surfactants (anionic â€“ sodium dodecyl sulfate, cationic â€“
cetyltrimethyl ammonium bromide, and non-ionic â€“ T X-100) are used as micelle forming compounds.
Results and Discussion: Micellar-mediated reactions exhibited dramatic rate accelerations and
improvements in the yield of end products. The VH reactions pursued pseudo-first- and second-order
kinetics. Conclusion: This study with anisole is the first such report demonstrating a feasible, controllable,
non-toxic, and easy methodology for the synthesis of formylated and acetylated derivatives and a study of
their kinetic behavior.
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