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evaluated for preâ€compression parameters like bulk density, tapped density, angle of repose, carrs index, and hausnerâ€™s ratio.Press coated tablets were evaluated for hardness, thickness, friability, tensile strength, drug content, and in vitro drug release. In vitro release studies were performed for 24 hours, first 2 hours in 0.1 N HCl, 3 hours in phosphate buffer (pH 6.8), and then for 19 hours in phosphate buffer (pH 7.4). In vitro drug release studies revealed that the tablets coated with pHâ€dependent,enzymeâ€dependent, and timeâ€dependent polymers showed no drug release in 0.1 N HCl, except for tablets coated with Pectin (25% and 50%, w/w). Kinetic modeling showed that the release exponent (n) value for all formulations was >0.89,indicating super case II transport to be the drug release mechanism. Press coated tablets for colonic delivery of esomeprazole
magnesium trihydrate were successfully developed.
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