Formulation and evaluation of matrix tablets of miglitol using different grades of HPMC

Main Article Content

Prof. Narendra Yadav

Abstract

Miglitol is a secondâ€generation â€glycosidase inhibitor with a chemical structure of 1â€desoxynojiromycin. It acts as a
potent competitive inhibitor of the alfa glycosidase in the microvilli of the intestinal brush border. Miglitol has a short biological halfâ€life (2 h) and its bioavailability is >90%. Moreover, the site of absorption of miglitol is in the intestine.Therefore, the objective of the present work is to develop a sustained release matrix drug delivery systemfor the drug miglitol for the better management of the disease, to minimize sideâ€effects as well as to improve patient compliance using different grades of HPMC Kâ€4, HPMC Kâ€15 and HPMC Kâ€100 in different proportions and combinations by the direct compression technique.

Key words: Bioavailability, controlled release, direct compression technique, hydrophilic polymer, miglitol

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How to Cite
Yadav, P. N. (2014). Formulation and evaluation of matrix tablets of miglitol using different grades of HPMC. Asian Journal of Pharmaceutics (AJP), 8(4), 237–240. https://doi.org/10.22377/ajp.v8i4.449
Section
ORIGINAL ARTICLES