Method development of ramipril and atorvastatin calcium capsule by using simultaneous equation method and absorbance ratio method

Prof. J. S. Rajawat


Ramipril is an angiotensin‐converting enzyme inhibitor and atorvastatin calcium is inhibitor of 3‐hydroxy‐3‐ methylglutaryl‐CoA reductase used in the treatment of hypertension. Simple, precise, rapid and selective simultaneous equation and Q‐analysis methods have been developed for the simultaneous determination of ramipril and atorvastatin fromcombined capsule dosageforms.The methods involve solving of simultaneous equations and Q‐value analysis based on measurementabsorptivity at 210.030 and 246.828 nm, respectively. Linearity lies between 2 and 25 mcg/ml for both drugs.

Key words: Absorbance ratio method, atorvastatin, ramipril, simultaneous equation

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