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w/v, 0.75% w/v and 1.0% w/v). The prepared formulations were evaluated for thickness, weight variation, percentage drug content, surface pH, folding endurance, percentage moisture absorption and loss, percentage swelling, mechanical strength and in vitro transcorneal permeation. In vitro transcorneal permeation study was performed on goat cornea using
a modified Franz diffusion cell. The inserts were found to be of uniform thickness (ranging from 51.230 Â± 0.385 Î¼m to 109.275 Â± 0.522 Î¼m) and weight (1.720 Â± 0.079 mg to 3.402 Â± 0.105 mg). The % drug content in the inserts was found
to vary between 95.450 Â± 0.427% and 98.471 Â± 0.225.The cumulative % drug releases from the formulation ranged from 38.19 to 75.21 over a period of 24 h. All the formulations followed a zero order release pattern. The in vitro transcorneal study revealed that an increase in concentration of the polymer slowed down the release of ofloxacin from the formulation.Ocular inserts using guar gum as a polymer were successfully prepared and can be effectively used for sustained ocular delivery over a period of 24 h.
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