Applicability of Vesicular Formulation in the Delivery of Hydrophobic Drugs

Abstract

The delivery of hydrophobic drugs has posed significant challenges in the field of pharmaceuticals due to their
poor aqueous solubility and low bioavailability. Vesicular formulations, such as transferosomes and liposomes,
have shown promise as effective medication delivery methods to address these issues. The application of vesicular
formulations in improving the solubility, stability, and targeted delivery of hydrophobic medicines is summarized
in this abstract. Because of their special bilayer structure, vesicular carriers can encapsulate hydrophobic medicines
in their lipid or surfactant membranes, improving their solubility and bioavailability. Furthermore, vehicles can
hold a variety of pharmacological compounds due to their flexibility. Phospholipid bilayers form liposomes,
which have been thoroughly studied and could transport either hydrophilic or hydrophobic medications. In
addition, interesting platforms for drug packaging and delivery are biosomes, which are made of non-ionized
and transferosomes, which contain edge activators. Modifying vesicles with ligands or antibodies that identify
receptors on target cells or tissues can enable the targeted administration of hydrophobic medicines. As a result,
there are fewer side effects and better therapeutic results due to targeted medication distribution. To sum up,
the distribution of hydrophobic medicines can be achieved through the diverse and efficient use of vesicular
formulations. They offer solutions for enhancing drug solubility, stability, and bioavailability, as well as enabling
targeted and controlled drug release. The continued exploration of vesicular carriers in drug delivery systems
holds great promise for improving the therapeutic efficacy of hydrophobic drugs and expanding the possibilities
of pharmaceutical science.