The Role of Flavonoids in Mitigating Oxidative Stress: Mechanisms, Applications and Therapeutic Potential

Abstract

Oxidation is a fundamental aspect of aerobic life processes, involving a reaction in which either electrons or
hydrogen are transported from an element to an oxidizing mediator, resulting in the creation of free radicals.
Oxidative stress is generally a result of an inequity between reactive oxygen species production and the
antioxidant level of a biological system. This is the key factor in the advancement of numerous pathological
conditions, such as cardiovascular and neurodegenerative disorders. Flavonoids are an extraordinary class of
plant secondary metabolites that have been traditionally utilized as medicines, offering scientifically validated
therapeutic benefits. The use of phytochemicals, particularly flavonoids, in the prevention and treatment of
diseases is well recognized. Fruits, as well as green vegetables, are natural sources of flavonoids. For humans,
recent studies have primarily concentrated on the beneficial effects of flavonoids on well-being. The flavonoids
are classified into six different subclasses based on their ring structure. In the present review work, we have
focused on the effect of flavonoids and its mechanism in reducing oxidative stress and, ultimately, various
disorders. Flavonoids mainly produce their antioxidant effect through neutralizing free radicals, inhibiting
enzymes responsible for the generation of free radicals, formation of chelates with metal ions, and stimulating
the internal antioxidant defense system. We have also highlighted the therapeutic potential of flavonoids as
future therapeutic agents.