Nanoemulsion Formulation and Evaluation of Terminalia chebula Fruit to Improve Bioavailability

Abstract

Terminalia chebula is a reputed medicinal plant with various therapeutic characteristics; however, it is limited
by poor solubility and permeability, leading to low bioavailability. A novel nanoemulsion-based formulation was
developed and evaluated to improve the aforementioned properties. The nanoemulsion was prepared using oil in
water method with appropriate surfactants and cosurfactants to increase the solubility and stability of bioactive
compounds in T. chebula fruit extract. To explore its properties, the formulation was characterized for parameters
such as particle size, zeta potential, polydispersity index, and stability under different conditions. In vitro release
studies indicated a considerably enhanced dissolution rate as against that of conventional extracts, the presence
of augmented bioavailability was further corroborated through the enhanced pharmacokinetics parameters in the
in vivo studies. This approach upholds a real strategy to maximize therapeutic efficacy associated with T. chebula
substances, pointing toward their use in developing effective herbal medicine.