Hyperactivity of the Inferior Oblique Muscle in the Human Eye: Histopathological Study
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Abstract
Background: Awareness of the impact of the various surgical treatments requires an awareness of a slightly
different architecture of the inferior oblique (IO) muscle in comparison to the other extraocular muscles.
The IO muscle’s anatomy has been linked to particular clinical diagnoses in a number of investigations.
Aims of Study: To establish a correlation between the various levels of clinical overaction and the histological
alternations of the IO muscle. Materials and Methods: Once the clinical severity of the muscle over-action
was established, 10 samples from the IO muscles were obtained during the strabismus surgery. As a control,
one muscle biopsy was obtained during enucleation surgery. A light microscope was used to examine each
biopsy. Results: Grade II and grade III IO overaction revealed numerous histological abnormalities under light
microscopy, including fibro-fatty infiltrations, nerve bundle enlargement, muscle fiber degeneration, and varied
muscle fiber size. Fatty infiltration, mononuclear infiltration, and perimysium and endomysium fibrosis were
observed in grade III IO overaction. Conclusion: The clinical stages of muscle overaction are correlated with
histopathological alterations in the IO muscle.
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