Aquasomes: Self-assembled systems for the delivery of bioactive molecules

Main Article Content

Neha Narang

Abstract

Nanocarriers increase the therapeutic efficacy of the pharmaceutically active agents as they can regulate their release, improve their stability and prolong circulation time by protecting the drug from phagocytosis and premature degradation.These delivery vehicles have the potential to augment the pharmacodynamic and pharmacokinetic profiles of drug molecules, thereby enhancing the therapeutic efficacy of the pharmaceutical agents. Nanoparticles which are fabricated from ceramics
consist of a hydroxyapatite core whose surface is noncovalently modified by oligosaccharide on which bioactive material/drug can be absorbed, are known as “aquasomes.â€Â  This review involves properties, advantages, preparation methods, evaluation,and applications of aquasomes.

Downloads

Download data is not yet available.

Article Details

How to Cite
Narang, N. (2014). Aquasomes: Self-assembled systems for the delivery of bioactive molecules. Asian Journal of Pharmaceutics (AJP), 6(2). https://doi.org/10.22377/ajp.v6i2.61
Section
Articles

References

Moghimi SM, Hunter AC, Murray JC. Nanomedicine: Current status and

future prospects. FASEB J 2005;19:311-30.

Mandal SC, Mandal M. Current status and future prospects of new drug

delivery system. Pharma Times Magazine 2010;42:13-6.

Patil S, Pancholi SS, Agrawal S, Agrawal GP. Surface-modified

mesoporous ceramics as delivery vehicle for haemoglobin. Drug Deliv

;1:193-9.

Pandey RS, Dixit VK, Sahu S, Sudheesh MS, Madan J, Kumar M.

Carbohydrate modified ultrafine ceramic nanoparticles for allergen

immunotherapy. Int Immunopharmacol 2011;11:925-31.

Khopade AJ, Khopade S, Jain NK. Development of hemoglobin

aquasomes from spherical hydroxyapatite cores precipitated in the

presence of half-generation poly (amidoamine) dendrimer. Int J Pharm

;241:145-54.

Oviedo IR, Salazar-L Ìopez RA, Reyes-Gasgab J, Quirino-Barreda CT.

Elaboration and structural analysis of aquasomes loaded with

Indomethacin. Eur J Pharm Sci 2007;32:223-30.

Kommineni S, Ahmad S, Vengala P, Subramanyam CV. Sugar coated

ceramic nanocarriers for the oral delivery of hydrophobic drugs:

Formulation, optimization and evaluation. Drug Dev Ind Pharm

;38:577-86.

Wani AN, Yerawar SU. Aquasomes: A novel nanocarrier for drug delivery.Int J Pharm and Tech 2010;2:446-57.

Kossovsky N, Gelman A, Rajguru S, Nguyen R, Sponsler E, Hnatyszyn HJ,et al. Control of molecular polymorphisms by a structured carbohydrate/ceramic delivery vehicle-aquasomes. J Contrl Release 1996;39:383-8.

Yun K, Veerapandian M. The state of the art in biomaterials as

nanobiopharmaceuticals. Digest J Nanomat Biost 2009;4:243-62.

Goyal AK, Rawat A, Mahor S, Gupta PN, Khatri K, Vyas SP. Nanodecoy

system: A novel approach to design hepatitis B vaccine for

immunopotentiation. Int J Pharm 2006;309:227-33.

Rege K, Huang HC, Barua S, Sharma G, Dey SK. Inorganic nanoparticles for cancer imaging and therapy. J Control Release 2011;155:344-57.

Kossovsky N, Gelman A, Sponsler EE, Hnatyszyn HJ, Rajguru S, Torres M,et al. Surface-modified nanocrystalline ceramics for drug delivery

applications. Biomaterials 1994;15:1201-7.

Jain NK, Umamaheshwari RB. Control and novel drug delivery systems.

In: Jain NK, editor. Pharmaceutical product development. Vol. 21. New

Delhi: CBS Publishers and Distributors; 2006. p. 419-55.

Jain SS, Jagtap PS, Dand NM, Jadhav KR, Kadam VJ. Aquasomes: A novel drug carrier. Journal of Applied Pharmaceutical Science 2012;2:184-92.

Shahabade GS, Bhosale AV, Mutha SS, Bhosale NR, Khade PH,

Bhadane NP, et al. An overview on nanocarrier technology- Aquasomes.

J Pharm Res 2009;2:1174-7.

Umashankar MS, Sachdeva RK, Gulati M. Aquasomes: A promising carrierfor peptides and protein delivery. Nanomedicine 2010;6;419-26.

Leclerc L, Chauvierrea C, Mardenb MC, Vauthiera C, Labarrea D,

Couvreura P. Heparin coated poly (alkylcyanoacrylate) nanoparticles

coupled to hemoglobin: A new oxygen carrier. Biomat 2004;25:3081-6.

Kossovsky N, Gelman BA, Hnatyszyn HJ, Rajguru S, Garrell RL, Torbati S,et al. Surface-modified diamond nanoparticles as antigen deliveryvehicles.Biconjugate Chem 1995;6: 507-11