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binders in fluid bed granulation. To evaluate the influence of formulation variables (levels of HPMCâ€”Methocel K100 M and Surelease E7 19010) on drug release during a period of time of 12 hours, and on the kinetic release, a full factorial
experimental design with two factors and three levels was used. The formulation factors were the granulation polymer concentration and the matrix-forming polymer concentration. The obtained results have shown that the percentage of the drug released during the 12 hours is influenced both by the Methocel ratio and the Eudragit NE ratio; increasing the ratios of Eudragit and Methocel leads to the decrease of the percentage of the released drug.The influence of Eudragit NE percentage is maximum at four and six hours, but the influence of Methocel K100 M concentration is almost the same at all sampling times; all studied formulations showed a kinetic release that fitted best with the Peppas model.
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