Overview of Multi-Unit Pellet Systems
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Abstract
When an elderly patient requires a customized release pattern for a medication, an oral route of administration
presents a challenge because the patient may find it difficult to swallow. In situations where rapid disintegration
without sacrificing the original release profile is preferred, multiparticulates are the recommended dose form.
As will be discussed later in this review article, compressed multi-particulate systems made using pellets have
a number of pharmacokinetic, pharmacodynamic, and commercial benefits. It covers not only the various kinds
of controlled-discharge pellets that may be condensed, forming multiple unit pellet systems (MUPS) but also the
characteristics of those pellets, the core material, and the compressible excipients that control how the pellets
compress. In addition, a thorough discussion of the physicochemical characteristics of pellets and MUPS formation
techniques is provided in this article.
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