Effect of Cyclosporine on the Cortex of the Kidney and the Ameliorative Effect of Melatonin: Microscopic and Ultrastructural Alterations
Main Article Content
Abstract
Background: Cyclosporine is a potent immunosuppressive medication that has been used to treat autoimmune
disorders and has enhanced the quality of life and survival rate of transplant recipients. However, a number of adverse
effects, chief among them nephrotoxicity, restrict its use. Melatonin is an endogenous hormone released by the
pineal gland. Melatonin has antioxidant qualities. Melatonin is an antioxidant found to reduce Cyclosporine toxicity.
Aim of the work: The study aims to discover the kidney’s reaction to cyclosporine exposure and explore the protective
function of melatonin. Materials and Methods: Thirty adult male albino rats were used in the research. They were
separated into three groups, with Group A serving as the control group and not receiving any medication. Ten rats in
Group B (the cyclosporine-treated group) were given a subcutaneous injection of cyclosporine at a dose of 15 mg/
kg/day for 40 days. Ten rats make up Group C, the group that received melatonin treatment. They were given the
same intraperitoneal injection of cyclosporine and melatonin at a dose of 1 mg/kg/day in saline. The specimens were
prepared for both light and electron microscopic examination at the completion of the study. Results: Cyclosporine
causes morphological alterations in the kidney, including lobulation of glomerular capillaries in the renal corpuscle and
enlargement of the urinary space with congestion. The proximal convoluted tubules had uneven cell degeneration and
brush boundary disintegration. The peritubular capillaries were clogged and extravasated, and the distal convoluted
tubules degenerated, with some cells inside the lumen exfoliating. In addition, the effects of cyclosporine are lessened
when melatonin is administered with it. Conclusion: Through oxidative stress, cyclosporine damages the kidneys,
while melatonin, an antioxidant, reduces but does not completely prevent these damages
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.