Investigation of In Vivo Anti-ulcer Activity of Extract of Drimiopsis kirkii Lindl. & Paxton Leaves

Abstract

A peptic ulcer is a prevalent gastrointestinal disorder characterized by mucosal erosion due to an imbalance
between protective and aggressive factors in the stomach. Medicinal plants are a rich source of natural antiulcer agents with fewer side effects compared to conventional therapies. Drimiopsis kirkii Lindl. & Paxton,
a bulbous herbaceous plant of the Asparagaceae family, is traditionally used for various ailments, including
inflammation and gastrointestinal disturbances. This study aimed to investigate the in vivo anti-ulcer potential
of D. kirkii leaf extract in experimentally-induced gastric ulcer models in rats. Extract of the leaves was
evaluated using aspirin and pylorus ligation-induced ulcer models. The extract demonstrated significant dosedependent ulcer protection, suggesting the presence of gastroprotective phytoconstituents such as flavonoids,
tannins, and saponins. The results validate the traditional use of this plant and indicate its potential as a natural
anti-ulcer agent.