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as a granulating binder, showing a substantial decrease in drug release in initial 5 h (16.28-16.7%) and releasing most of the drug in 12-24 h. The geometric and arithmetic mean diameter ranged from (490 to 780 Î¼m) and (636 to 734 Î¼m),
respectively. The minimum to maximum range for circularity, elongation and rectangle were found to be (0.847Â±0.009 to0.965Â±0.078), (1.036Â±0.057 to 1.185Â±0.023), and (0.724Â±0.041 to 0.791Â±0.047) respectively showing the proper shape and size of the pellets. The content of CXB in the prepared pellets was observed between 98.70 and 99.47% justifying the uniform drug distribution. The in vitro dissolution studies showed that the retardant effect in initial 5 h and most of the drug release in 24 h depended on the ratio and concentration of different grades of methacrylate polymers used in the formulation. CXB-loaded MUPS prepared by the extrusion-spheronization technique using polymethacrylate polymers showed immense potential for colon-specific drug delivery of the drug.
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