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spreadability, and viscosity for a topical anti-inflammatory effect.Three gelling agents were examined: Carbopol 974P, GantrezÂ AN 119, and Polyvinylpyrroloidone PVP K30. Skin permeation rates and lag times of NAP were evaluated using the Franz- type diffusion cell, in order to optimize gel formulation. The permeation rate of the NAP-based gel across excised rat skin
was investigated. A significant increase in permeability parameters such as steady-state flux (Jss), permeability coefficient (Kp), and penetration index (PI) were observed in the optimized formulation containing 2% Transcutol as a permeation enhancer. From the skin irritation test, it was concluded that the optimized novel tetraglycol-based gel formulation was safe to be used for transdermal drug delivery. The developed naproxen / glycofurol-based gel appeared promising for dermal and transdermal delivery of naproxen and could be applicable with water-insoluble drugs, which would circumvent most
of the problems associated with drug therapy.
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