Main Article Content
and lactose monohydrate as a hydrophilic filler.The potential of the intragranular addition of starch as a dissolution enhancer and a disintegrative agent was also evaluated. After analysis of their solid state was performed by means of x-ray powder diffraction (XRD), the granules were characterized from technological and dissolution point of view. The subsequent step comprised of the preparation and evaluation of the tablets, including the effect of the extragranular introduction of starch.Besides the remarkable enhancement of drug dissolution rate of the granulates in comparison to physical mixtures and pure drug, no significant differences were found between the dissolution profiles of the granulates containing lactose or starch.However, the difficult disintegration and bad dissolution performance of the tablets not containing intragranular starch so
it is necessary to add disintegrant in the granulating mixture. Moreover, the extragranular addition of a small amount of starch gave rise to further amelioration of the disintegration and dissolution performances.
This is an Open Access article distributed under the terms of the Attribution-Noncommercial 4.0 International License [CC BY-NC 4.0], which requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, for noncommercial purposes only.
Perissutti B, Rubessia F, Moneghini M. Formulation design of
carbamazepine fast- release tablets prepared by melt granulation
technique. Int J Pharm 2003;256:53-63.
Abberger T. Influence of binder properties, method of addition, powder
type and operating conditions on fluid-bed melt granulation and
resulting tablet properties, Pharmazie 2001;56:949-52.
Henck J. Mechanism of granule formation in fluid bed melt granulation
and their effects on tablet properties. Pharmazie 2000;55:521-4.
Chidavaenzi O. The effect of co-spray drying with polyethylene glycol
on the crystallinity and physical form of lactose. Int J Pharm
Doshi D. Carbamazepine and polyethylene glycol solid dispersions:
Preparation, in vitro dissolution and characterization. Drug Dev Ind
Ford J. The preparation and properties of tablets containing
indomethacin and polyethylene glycol 6000. Pharm Acta Helv
Conte U, Manna A. Linear extended release of a water-insoluble drug,
carbamazepine, from erodible matrices. Int J Pharm 1993;94:15-22.